A differential scanning calorimetry analysis of the age-related changes in the thermal stability of rat skin collagen. Flandin F, Buffevant C. Bashey, R. I., Torii, S., and Angrist, A., Age-related collagen and elastin content of M., and Buffevant, C., Collagen heterogeneity in pig heart valves, Biochem. Semantic Scholar profile for C Buffevant, with fewer than 50 highly influential Evolution of structural and biochemical properties of rat skin collagen during.

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Collagen heterogeneity in pig heart valves.

The invention thus makes it possible to provide a biological reactant of high specificity and of which the constituents are of natural origin. Process of manufacture of biodegradable microcapsules having walls composed of crosslinked co,lagen and polyholosides. Use of a collagen as solid binding substrate for a ligand capable of reacting specifically with an element to be detected in a biological medium, reactant and implementation.

Composition containing liposomes stabilized by a stabilizing support based on atelocollagen and glycosaminoglycans. Particles, especially microparticles or nanoparticles, of crosslinked monosaccharides and oligosaccharides, processes for their preparation and cosmetic, pharmaceutical or food compositions in which they are present.

Biodegradable microcapsules having walls composed of crosslinked atelocollagen and polyholoside. The invention relates to microcapsules with a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, and to processes for the manufacture of the said microcapsules. These particles comprise at least on the surface thereof a wall composed of a mixture of at least one collagej and at least one polysaccharide which are cross-linked, preferably by interfacial cross-linking with a polyfunctional acylating agent which forms at least amide and ester bonds, and optionally anhydride bonds with amine, hydroxyl or carboxyl functions of the protein and of the polysaccharide, and which comprise hydroxamic groups on the surface thereof for chelating metal ions.

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Preferably, the solid substrate comprises atelocollagen or a mixture of atelocollagen and of polyholoside. These particles can be used in cosmetics or in pharmacy notably for the chelation or release of metal ions. The preferred use of this composition is in pharmacy or beauty care. Chantal Buffevant has filed for patents to protect the following inventions. These microcapsules can be manufactured either by a process involving interfacial crosslinking or by the extrusion of a laminar flow which is broken up by vibrations into individual droplets, which fall into a crosslinking bath.

It can be used easily and quickly. Particles of cross-linked proteins and polysaccharides with hydroxamic groups for chelating metals and their uses notably in cosmetics. The invention relates to small sized particles.

C Buffevant

Said microcapsules or microspheres contain an active food, cosmetic or pharmaceutical ingredient and are hence used in the preparation of food, cosmetic or pharmaceutical compositions. The invention concerns the production of polysaccharide wall microcapsules or microspheres containing primary alcohol functions crosslinked by a crosslinking agent. Eric Perrier, Chantal Buffevant. Particles of crosslinked plant proteins and the process for their preparation.

Particles comprising an outer wall formed of one or more saccharide components selected from the group consisting of monosaccharides and oligosaccharides crosslinked by interfacial crosslinking in emulsion, preferably at room temperature, with a polyfunctional acylating crosslinking agent to produce ester linkages between the acylatable hydroxyl group s of the primary alcohol s of the saccharide component and the acyl groups of the polyfunctional acylating agent.


These particles can be used for the manufacture of cosmetic, pharmaceutical and food compositions.

These particles comprise, at least on the surface, a wall formed of plant proteins crosslinked particularly by means of interfacial biffevant between the plant proteins and an acylating polyfunctional crosslinking agent comprising at least two acylating groups, covalent bonds being formed between the acylatable groups of the proteins and the acyl groups of the acylating polyfunctional crosslinking agent.

These particles are used for the buffdvant of a cosmetic, pharmaceutical, dermatological or food composition.

Polysaccharide wall microcapsules containing primary alcohol functions and compositions containing same. The invention relates to particles. These microcapsules are biocompatible by virtue of the presence of atelocollagen, which has most of the advantageous properties of collagen, namely a very low antigenicity and a perfect biodegradability. The invention relates to the use of collagen as solid binding substrate for a sensor called ligand or refining agent, capable of reacting specifically with an element to be detected in a biological medium, to form a specific complex.