Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.

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Further investigation of potential factors that may influence the survival of these patients should be encouraged through longer follow-up periods and larger samples. The palate was the most commonly affected site, with 21 cases Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland.

International Journal of Morphology. R; Milanezi, E; Olson, S. Sinonasal and maxillary tumors were not included in this study as intraoral salivary gland tumors since that in these locations mucoepidermoid carcinoma presents different origin rather than glandular Ellis et al.

Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: The three-level grading system commonly used by pathologists for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth patterns cystic, solid, or infiltrativetogether with neural and vascular invasion.

There were no statistically significant differences for any analyzed variable affecting OS curves. The broad age range observed in our series supports that reported in literature.

Mucoepdermoide access to EBSCO’s databases is permitted to patrons of subscribing institutions accessing mucoepidermoixe remote locations for personal, mucoepidermlide use.

Mucoepidermoid carcinoma of the salivary glands -clinical review of 42 cases. Microscopically, most intraoral MEC were classified as low grade of maligancy 27cases – The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood.

Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

The 5 and year overall survival rates were glanulas Few papers evaluating only one type of oral salivary gland tumors are available. Discrepancies were solved by consensus. A total of 16 cases were analyzed over a period of 18 years; males were MECs were staged according to the TNM classification of malignant tumors, 12 and minor salivary gland tumors were staged according to their site of origin in a similar fashion to squamous cell carcinomas.


Histopathologic grading of salivary gland neoplasms. Mucoepidermoid carcinoma of the salivary glands: English Copyright of International Journal of Morphology is the property of Sociedad Chilena de Anatomia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder’s express written permission. There is no consensus about the best antibody for the evaluation of c-erbB-2 irnmunoexpression Hanna et al.

Carcinoma mucoepidermoide

HER2 expression in salivary gland carcinomas: The use of skim milk as an economical and effective substitute for commercial biotin solutions. Mucoepidermoid carcinoma of minor salivary glands: Data concerning survival recurrence and metastasis were evaluated.

MEC is reported to manifest variable biologic aggressiveness, basically showing correlation with its histological features and is graded by a 3-tiered system Auclair et al, Mucoepidermoid carcinoma MEC is the most common malignant neoplasm of major and minor salivary glands Lopes et al, We undertook this study to analyze the histological grade and proliferative potential as prognostic factors, important to guide the treatment and design recommendations, in a series of 13 patients who were treated for MEC of principal and accessory salivary glands between and Head Neck, 26 4: Expression of c-erbB-2 oncoprotein in salivary gland tumours: Casilla D Temuco – Chile Tel.: Further studies in order to clarify this point are warranted.

Thus, our findings may suggest the lack of association among clinicopathological features and the immunoexpression of c-erbB Blocking of endogenous avidin-botin activity in immunohistochemistry. Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.

There is a wide variation in these malignant neoplasms over different geographic areas and ethnic groups. Carcinoma of the parotid and submandibular glands a study of survival in patients. The association among clinicopathological features and c-erbB-2 oncoprotein expression was evaluated in twenty-nine cases of intra-oral mucoepidermoid carcinoma MEC.

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Mucoepidermoid carcinoma of the head and neck: Although MEC has been described as a radioresistant tumor, postoperative radiotherapy has been associated with carinoma recurrence in some reports. Survival curves were generated using the Kaplan-Meier method and analyses were performed using mucoepisermoide log rank test. Cytoplasmic expression of c-erbB2 in non-small cell lung cancers. In our series, patients demonstrated an earlier average age of occurrence, with a peak of incidence in the third and fourth decades of life, whereas previous studies described a prevalence in fifth and sixth decades of life Auclair et al.

Carcinoma mucoepidermoide

In our series the results were similar with 21 Previous studies of c-erbB-2 expression in salivary gland carcinomas are sparse, comprise heterogeneous subtypes, and show contradictory results Locati et al. The OS was defined as the interval between the beginning of the treatment and the date of death or last information for censored observations. However, many studies found that benign and malignant salivary gland neoplasms with evidence of myoepithelial lineage do carcinom overexpress c-erbB-2 protein which support the view that this growth receptor is not involved in their pathogenesis Rosa et al.

Ann Otol Rhinol Laryngol.

From oral biopsies submitted during period between and ,40 0. This antibody although less sensitive than the polyclonal antibody used in other carclnoma Lopes et al. Mucoepidermoid carcinoma of the major salivary glands: Two oral pathologists reviewed all cases to histopathologically classify these tumors according to the protocol published by Brandwein and others 10which classifies tumors into low Grade Iintermediate Grade II or high Grade III grades.

Rare expression of mucoeipdermoide c-erbB-2 oncoprotein in salivary gland tumors: